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A preclinical safety evaluation published in ScienceDirect confirmed that BPC-157 showed no test-related toxicity in single-dose and repeated-dose studies across mice, rats, rabbits, and dogs, with no genetic or embryo-fetal toxicity detected

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For instance, low IGFBP-1 levels with high C-reactive protein values are strong predictors of MetS [252, 253]

Novel pan-ERR agonists ameliorate heart failure through enhancing cardiac fatty-acid metabolism and mitochondrial function