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Figure 6 4 Discussion Exenatide has previously been shown to lower BMI ( Endogenous active GLP-1 has an in vivo half-life of a couple of minutes, due cleavage by DPP-4 yielding the inactive metabolite GLP-1 (936) amide ( The present finding that exenatide lowers DPP-4 levels is important because circulating DPP-4 levels are elevated in obesity, regardless of glucose tolerance ( Although glicentin showed considerable variability, we observed, overall, a slight increase of glicentin levels

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