The affected medications include: Semaglutide (Ozempic, Rybelsus, Wegovy) Liraglutide (Saxenda, Victoza) Tirzepatide (Mounjaro, Zepbound) New Warning Details The updated label now includes a subsection under "Warnings and Precautions" that states: "There have been rare postmarketing reports of pulmonary aspiration in patients receiving GLP-1 receptor agonists undergoing elective surgeries or procedures requiring general anesthesia or deep sedation who had residual gastric contents despite reported adherence to preoperative fasting recommendations." This warning highlights the potential risk of stomach contents entering the lungs during surgical procedures, even when patients have followed fasting guidelines
If a patient has been off tirzepatide for an extended period or previously experienced significant gastrointestinal side effects, consider restarting at a lower dose than the pre-surgical maintenance dose, then titrating upward over subsequent weeks
Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, et al
Younger skin tends to rebuild collagen more readily, but mature skin still responds well, especially across a full series
