First, let's consider the protection of the collagen matrix
In some embodiments, the formulation or composition has a retention time in the ear of about 5 minutes, about 15 minutes, about 30 minutes, about 1 hour, about 4 hours, about 6 hours, about 12 hours, about 18 hours, about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 6 days, about 7 days, about 10 days, about 12 days, about 14 days, about 18 days, about 21 days, about 25 days, about 30 days, about 45 days, about 2 months, about 3 months, about 4 months, about 5 months, about 6 months, about 9 months or about 1 year
Regulatory cell death modalities include classical apoptosis, necroptosis, pyroptosis and ferroptosis, with ferroptosis as a novel regulatory cell death driven by iron-dependent lipid peroxidation, is regulated by intracellular iron metabolism, lipid metabolism, the GSH/GPX4 repair system, coenzyme Q10, and other genes 26,27,28,29
A 1 mg dose would be a tiny 0.05 mL (or 5 units), which can be more difficult to measure accurately
