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Of note, G6pdh chon growth plates also showed an increase in the metabolic pathways glycine, serine and threonine metabolism and one carbon pool by folate, both of which can produce NADPH, suggesting that mutant chondrocytes try to compensate, albeit unsuccessfully, for the reduced NADPH generation by the PPP (Fig

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Third, statins have proven to preserve cardiac function in animal models of myocardial hyper-trophy and heart failure, such as aortic banding, myocardial infarction, and several transgenic models (145, 150152)