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Collectively, four converging mechanismsBMP-SMAD activation, PI3K/FOXO3 modulation, angiogenic remodelling and redox homeostasisexplain how PD-MSCs and their engineered derivatives revive endocrine and reproductive competence, setting the stage for precision stem-cell or secretome therapies that are both effective and minimally invasive
1 Introduction Melanoma is one of the most aggressive cancers due to its high metastatic potential and mortality rate (Greco and Cinquegrani, 2016), many of which exhibit antibacterial, antiviral, anti-inflammatory and anticancer activity (Molinski et al., 2009
Excitingly, in addition to the significant decrease in TSH levels, there was also a lever reduction in serum CXCchemokineligand-10 (CXCL10) chemokine which were induced by IFN-
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