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Link to the PDF with some thoughts below: fda.gov/media/193343/d The FDA reviewed 5 reports with 109 humans: 24 healthy volunteers rectal 53-person Ulcerative Colitis trial rectal 17 knee-pain patients intra-articular 12 bladder-pain patients intravesical 2 healthy volunteers IVThe FDA has 4 broad reasons against BPC: 1

In women with mild tubal disease affecting the portion of the tube closest to the ovary, surgery to open the tube can improve fertility, although it also increases the risk of ectopic (tubal) pregnancy

This product melts into the skin when it comes into contact with moisture, and it's best applied on very damp skin for optimum absorption