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Fatigue that doesn't improve after four to six weeks at a stable dose, fatigue severe enough to interfere with daily function, or any fatigue accompanied by concerning symptoms is worth flagging with your prescriber

The FDA recommends using non-oral contraceptives or adding a barrier method for 4 weeks after initiation and after each dose increase when taking tirzepatide with oral contraceptives

Neeland is the Director of Cardiovascular Prevention and Co-Director of the Center for Integrated and Novel Approaches in Vascular-Metabolic Disease at University Hospitals Harrington Heart & Vascular Institute, and Associate Professor of Medicine at Case Western Reserve University

Ganachari, KLE Technological University, India Updates Copyright 2025 Tian, Xu, Liu, Wang, Wu, Li and Liu