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Deficiencies in B12 or defects in methionine synthase will result in 5-methyl-THF trapping with the result being the development of megaloblastic anemia due to the block in nucleotide production and the inability of bone marrow erythroblasts to proceed through S-phase of the cell cycle

Pharmaceutics 14 (9), 1890

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It is important to recognise that marketing claims linking B12 supplementation directly to weight loss are not supported by robust clinical evidence from UK or international health authorities