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For example, AS involves the toxic accumulation of lipids in vessel walls, and in AS-related cells, such as macrophages, vascular smooth muscle cells, and endothelial cells, GPX levels are low, iron metabolism is dysregulated, and ROS are elevated [13, 14]

Ramachandra, a bariatric and general surgeon at Trinity Health Mid-Atlantics Mercy Fitzgerald Hospital

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Beyond pharmacotherapy, emerging evidence suggests that gut microbiotaderived metabolites and postbiotics, such as short-chain fatty acids (SCFAs) and tryptophan-derived indoles, can modulate enteroendocrine function, inflammatory tone, insulin sensitivity, and gutbrain communication