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Head-to-Head Efficacy: Tirzepatide Wins 22% vs 15% Weight Loss The most robust head-to-head comparison comes from the SURPASS-2 trial, a 40-week, phase 3 study of 1,879 adults with type 2 diabetes, published in the N Engl J Med

Any use should be considered adjunctive to standard care, and patients should continue to monitor their symptoms and discuss their management with healthcare professionals

Further potentiation of SDF-1 could activate deleterious neurohormonal systems [74, 75], interact unfavorably with concurrently administered beta-adrenergic receptor blockers [71, 76], and promote progenitor cell infiltration, cardiac inflammation and adverse cardiac remodeling [77,78,79]

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