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Moreover, most of the existing preclinical studies have relied on male rodents, neglecting sex-specific variants in gut microbiota compositions and neuroinflammatory responses (Chakraborty et al., 2025)

The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes

Eli Lilly emerges as the biggest winner, not only does it have the GLP-1/GIP dual agonist Tirzepatide (brand name Mounjaro) approved in the US for weight reduction indications, but it also has a GLP-1 small molecule drug Orforglipron advancing in Phase III clinical trials

Cellular Repair : It assists in repairing damaged DNA and proteins, thereby promoting overall cellular health