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This disease occurs in about 820 per 100,000 people, affecting approximately 2754 million people worldwide ( Studies have found that the best predictor for islet autoimmunity is genetic background, with predisposition caused by genetic susceptibility in multiple loci, including INS and the class I and II Major Histocompatibility Complex (MHC)/human leukocyte antigen (HLA) genes ( Figure 1 ) ( Figure 1 )

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Additionally, either it has spread to four or more lymph nodes