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In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]

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Because the incidence of B12 deficiency is so high among thyroid patients I often recommend that every thyroid patient takes a B12 supplement (or at least takes B12 in one or more of their supplements) in some form