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Although its pathogenesis remains unclear, over 80% of PSC patients have comorbid inflammatory bowel disease, suggesting shared immune dysfunction 61,62

En este escenario, los nuevos frmacos como los agonistas GLP-1 y las combinaciones con agonistas GPI son una nueva promesa no solo para ayudar a los pacientes a perder peso sino tambin para mantener esa prdida

As a result, clinical development of new AOMs will become more expensive and operationally more challenging, e.g., exacerbating the already intense competition for obese patients during trial recruitment, while more onerous inclusion/exclusion criteria will make finding eligible patients even harder

Simic, Tatjana (2018)