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Furthermore, galectin-3's association with adverse outcomes is independent of other clinical variables and co-biomarkers such as soluble suppression of tumorigenicity-2, underscoring its unique contribution to disease processes (137)

This means your peaks are sharper, your troughs are deeper (proportionally), and the wearing-off effect may be more pronounced

The evidence, the dosing rationale, the safety profile, and the ability to attribute any effect all get weaker as ingredients are added, because the number of unstudied interactions grows

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