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Initial therapy with the combination of JANUVIA and metformin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo, to metformin alone, and to JANUVIA alone (Table 8, Figure 1)

Substituting the C-terminal tail of GLP-1R with that of GIPR resulted in a small but significant increase in the extent ( E MAX ), but not potency, to which GLP-1 stimulated Venus-mG s recruitment to this receptor (Figure 2A

Without knowing the target, the mechanism of action remains incompletely understood, and it is not possible to optimize the peptide-receptor interaction or predict off-target effects

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