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In spite of the association of excess IGF-2 with tumours, in general it is clear that IGF-1 plays a major role in development, growth, cell differentiation, and maintenance of skeletal muscles, both in culture and in intact animals

41 , 42 This metabolicinflammatory interplay amplifies neuroimmune signalling, culminating in synaptic dysfunction, neuronal energy failure, and progressive loss of structural plasticityhallmarks of insulinresistant neurodegeneration

This helps avoid irritating and inflaming the scar tissue around it

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