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Reported Effects Weight reduction (no diabetes): In REDEFINE 1, CagriSema 2.4 mg + 2.4 mg produced roughly 22.7% mean weight loss at 68 weeks (trial-product estimand), though this fell short of the ~25% Novo Nordisk had guided toward [1]

30 (Suppl 3) S264-269

Semaglutide's extended half-life (approximately 7 days) means the medication accumulates in the bloodstream with each weekly injection, creating prolonged effects on blood pressure and fluid balance compared to shorter-acting GLP-1 agonists

On the other hand, develop more long-acting injections, such as injections with one injection every two weeks and stable blood concentration, to prolong the action time of peptide drugs in the body