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Thyroid concerns emerged during clinical trials when rodent studies showed semaglutide increased thyroid C-cell proliferation, prompting a contraindication for patients with personal or family histories of medullary thyroid cancer or multiple endocrine neoplasia type 2

Impact of gastrointestinal adverse events on weight loss (STEP 13) Among participants on treatment at week 68 with a body weight assessment, the observed placebocorrected weight loss from baseline to week 68 for semaglutide 2.4 mg was 14.4 percentage points in the STEP 1 trial, 7.6 percentage points in the STEP 2 trial and 12.7 percentage points in the STEP 3 trial

-Tocopheryl esters (e.g., -tocopheryl acetate) from supplements or food fortificants must be hydrolyzed by pancreatic esterases to release -tocopherol for incorporation into micelles

Once approved, your oral semaglutide is delivered to your home, accompanied by ongoing provider support