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The lower mean weight loss in ATTAIN-1 may relate to the increased proportion of male participants, who are known to lose less weight than women during GLP-1 RA treatment

Nrf2 not only increases the enzyme levels of both the oxidative and non-oxidative arms, but it also facilitates the utilization of ribose 5-phosphate for the purine nucleotide synthesis (Mitsuishi et al., 2012), which appears to maintain the ribose 5-phosphate concentration at a low level and efficiently divert glucose flux into purine nucleotide synthesis through both arms of the pentose phosphate pathway