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Another network meta-analysis indicated that rifaximin is associated with significant improvement in CHE, supporting the role of rifaximin as an effective therapeutic option in the early stages of the disease [123]

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Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011

By adopting the recommended methodology, commenters explained that more code combinations would be eligible for complexity adjustments