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Furthermore, glutamate concentrations are reduced in frontal areas in experimental and clinical pain (Thompson and Neugebauer, 2019), and a frontal glutamatergic dysfunction has been implicated in depression as well (Moriguchi et al., 2019)

Yue et al., 2006

Since 2015, large-scale cardiovascular outcome trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce the risk of major adverse cardiovascular events, cardiovascular mortality, and heart failure hospitalization in patients with T2DM and established cardiovascular disease or high-risk profiles

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