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Interestingly, the tissues of the HFD-fed mice showed a significant decrease in the mRNA levels of the GSH-biosynthesis genes ( NRF2 , GCLC , and GCLM ), VD regulatory genes ( CYP2R1 , CYP27A1 , CYP27B1 , VDBP , and VDR ) in the liver, and of GSH-metabolism genes and GLUT4 gene transcription factors (VDR/PGC-1) in the skeletal muscle compared to those of mice that consumed a normal diet [44,47]

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