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B., Bate, G
Studies in knock-out mice confirmed the biological action of [dA(2)]GLP-1/GcG which is related to its ability to target GIP, GLP-1, and glucagon receptors
These preclinical insights have been validated in large-scale clinical trials.The FLOW trial (n = 3,533) showed that once-weekly subcutaneous administration of semaglutide (1.0 mg) significantly reduced the risk of a renal composite endpointincluding 50% decline in eGFR, renal failure, or cardiovascular deathby 24% in patients with T2DM and chronic kidney disease (CKD) (HR = 0.76, 95% CI: 0.660.88
reduction in liver fat content liver fat accumulation is correlated with several metabolic disturbances including low HDL and elevated triglyceride levels(Tushuizen et al, 2006)
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