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The article says to contact a provider if leg cramps are severe, persistent, or accompanied by swelling, weakness, or dark urine, which it flags as possible signs of rhabdomyolysis or serious muscle injury

Apart from reward, this initial AUD phase is influenced by the motivation to consume alcohol, which is another factor controlled by GLP-1R in male rats

Direct nutrient stimulation may induce the initial release of GLP-1 from small intestinal EECs, while large intestinal EECs likely release GLP-1 via a neural hormonal reflex or from microbe-derived metabolites, although this remains to be explored 93,99 (see the Gut microbiotabrain connection section)

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