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ROS Reactive Oxygen Species Tf Transferrin TfR1 Transferrin Receptor 1 BMECs Brain Microvascular Endothelial Cells DCYTB Duodenal Cytochrome B STEAP3 Six-Transmembrane Epithelial Antigen of Prostate 3 DMT1 Divalent Metal Transporter 1 LIP Labile Iron Pool FPN Ferroportin GSH Glutathione GPX4 Glutathione Peroxidase 4 PUFAs Polyunsaturated Fatty Acids NADPH Nicotinamide Adenine Dinucleotide Phosphate GSSG Oxidized Glutathione RSL3 RAS-Selective Lethal compound 3 PTE Post-Traumatic Epilepsy GABA Gamma-Aminobutyric Acid TSC Tuberous Sclerosis Complex FCD Focal Cortical Dysplasia TLE Temporal Lobe Epilepsy HS Hippocampal Sclerosis LPCAT3 Lysophosphatidylcholine Acyltransferase 3 MTLE Mesial Temporal Lobe Epilepsy SE Status Epilepticus SUDEP Sudden Unexpected Death in Epilepsy GTCS Generalized Tonic-Clonic Seizures IOC Iron Overload Cardiomyopathy P-gp P-glycoprotein ION Ischemic Optic Neuropathy DFO Deferoxamine VPA Valproic Acid NTBI Non-Transferrin Bound Iron Fer-1 Ferrostatin-1 CQ10 Coenzyme Q10 LPO Lipid Peroxidation 15-HETE 15-Hydroxyeicosatetraenoic Acid AEDs Antiepileptic Drugs SWI Susceptibility Weighted Imaging AMD Age-related Macular Degeneration RPE Retinal Pigment Epithelium OCT Optical Coherence Tomography CoQ10 Coenzyme Q10 ACSL4 Acyl-CoA Synthetase Long Chain Family Member 4 MVA mevalonate Glossary References 1

This opens the door to using TDN or future optimized ODN-based compounds as a standalone treatment or as part of combination therapy

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It also has an antimicrobial effect and destroys colonies of microorganisms that cause infections in the respiratory, intestinal and genital tracts