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In both cases, I am finding the optimal pharmacologic dose for ongoing treatment

In another aspect, the present invention provides use of tirzepatide for the manufacture of a medicament for improving glycemic control in a subject having type 2 diabetes (T2D) and being treated with a 20 mg dose of tirzepatide once weekly for at least four weeks, but in need of additional glycemic control, comprising: increasing the dose of tirzepatide being administered to 25 mg once weekly

Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene, the direct target of every GLP-1 compound), MC4R (a melanocortin receptor central to satiety and energy balance), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) map the metabolic terrain any compound has to work through

Together, these findings suggest that aging and tooth loss initiate a Vmes-centered cascade of neurodegeneration, with consequences extending beyond impaired mastication to cognitive decline (Table 3)