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This study led to the identification of two novel candidate effector genes, SPRY4 and PAPPA (pregnancy-associated plasma protein A), these genes may be involved in gene regulation through enhancer-promoter interactions [26]

Depending on cellular state and stress cues, TP53 can promote ferroptosis by repressing SLC7A11 to limit cystine uptake and GSH synthesis, inducing spermidine/spermine N1-acetyltransferase 1 ( SAT1 ) to enhance ROS generation through polyamine catabolism, and upregulating glutaminase 2 ( GLS2 ) to increase -ketoglutarate production and mitochondrial ROS 154-156

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N terminally MRGS(H) 6 -tagged wild type and mutant ScGrx7, PfGrx and PfGR were expressed in E