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According to the evolutionary and sequence diversity, microsomal GSTs have been identified to be the integral membrane proteins and are known as M embrane- A ssociated P roteins in E icosanoid and G lutathione M etabolism (MAPEGs)

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I think this highlights the fact that these drugs need to be used the way they were intended, not for a short stint, and with appropriate support from providers. Side effects are really variable