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Further, 79% to 86% of patients in the 8 mg and 12 mg groups, respectively, achieved liver fat content below the 5% threshold at week 24, with 89% and 93% achieving this endpoint at week 48

These medications are generally designed for long-term use to help maintain weight loss, underscoring the fact that obesity is a chronic disease that necessitates ongoing treatment and lifestyle modification

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Key Factors That Can Seriously Influence the Timeline So, why isn't there one single answer to "how long does it take to work?" Because a host of factors can accelerate, decelerate, or otherwise modify the timeline