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Understanding why this occurs is essential for planning sustainable maintenance strategies

doi: 10.1016/j.bbagen.2007.10.020

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The combination of large extracellular domains (ECD), extended orthosteric binding sites, and conformational flexibility makes class B1 GPCRs interesting but challenging targets for rational ligand discovery and particularly demanding benchmarks for computational ligand design and virtual screening methodologies (Aksu et al., 2024