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On the general safety profiles of ICI agents, a head-to-head comparison of 36 phase 1 and phase 2 clinical trials that enrolled 15,370 patients found that the safety ranking of ICIs as follows: Atezolizumab (pooled incidence 66.4%, probability 76%), Nivolumab (71.8%, 56%), Pembrolizumab (75.1%, 55%), Ipilimumab (86.8%, 55%) and Tremelimumab (not applicable (NA), 54%)

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