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The anti-adipogenic effect of PGF2 is mediated through prostaglandin F receptor-mediated elevation in intracellular calcium and DNA synthesis [168] and activation of MAPK, causing reduction in PPAR phosphorylation [169]

Tirzepatide may not be suitable for everyone, and using it without medical guidance can increase the risk of side effects, incorrect dosing, or unsafe use

(2002) 283:E11351143

Furthermore, TMAO exacerbates VC through dose-dependent vascular smooth muscle cell calcification and activation of the NLRP3 inflammasome and NF-B signaling (Zhang et al., 2020), thereby further promoting thrombosis (Figure 6)