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Melanotan-2 remains the only available pharmacological tool allowing the simultaneous study of the relative contributions of the four MCR receptors using selective antagonism protocols (HS024 for MC4R, JNJ-10229570 for MC3R, etc.)

If your research rationale genuinely requires high-dose exploration, calculate injection volumes using maximum practical concentration (10mg/ml) and consider dividing doses across multiple injection sites if individual volumes exceed 0.3ml to avoid tissue irritation and ensure complete absorption

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