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What Clinical Trials Show In clinical trials of FDA-approved semaglutide (Wegovy) and tirzepatide (Zepbound): Semaglutide (Wegovy): In large clinical trials of FDA-approved products, average weight loss was meaningful over roughly 68 weeks when paired with lifestyle support (reduced-calorie diet and increased physical activity)

Studies show that the highest dose of semaglutide (2.4 mg weekly) leads to the greatest average weight loss of 15%

Understanding musculoskeletal side effects from the tirzepatide experience can help you differentiate between expected transitional effects and genuine concerns

Clinical trials have linked semaglutide, for example, with improvements in chronic kidney disease, blood pressure, certain types of heart failure, and even cognitive decline