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Standard synthetic ascorbic acid has good bioavailability at lower doses (around 200 mg), but as the dose increases to the therapeutic levels often required for chronic illness (1,000 mg or more), absorption rates drop drastically

Thus, it must act within the gut-brain axis, regardless of whether this action is direct or indirect

In rodent studies, AOD 9604 has been used to examine its effects on weight gain, fat burning, and fat breakdown and storage

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