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More than 680 PTMs have been identified in humans, ranging from the addition of simple functional groups (for example, methylation and acetylation) to large complex biomolecules (for example, complex glycans and small proteins) 1

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Catalase does not show significant activity under physiological conditions, due to its relatively low affinity for hydrogen peroxide but becomes an important enzyme when the concentration of H 2 O 2 is raised e.g., by exposing cells to drugs and chemicals that increase intracellular H 2 O 2 generation [18]