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Symptoms Suggesting Hypoglycemia Patients should contact their healthcare provider if fatigue is accompanied by: Shakiness, trembling, or sweating Confusion or difficulty concentrating Rapid heartbeat or palpitations Extreme hunger Irritability or mood changes These symptoms may indicate low blood glucose, particularly in patients taking semaglutide with insulin or sulfonylureas

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ELISpot and FluoroSpot Assays: Single-cell cytokine secretion assays provide a functional assessment of T-cell activation by measuring the release of Interleukin-2 (IL-2) and Interferon-gamma (IFN-) following challenge with the conjugate