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Tissue damage accumulates

A patient may need to track multiple signals to understand whether metabolic health is improving

Early follow-up usually focuses on: Tolerance: nausea, fullness, bowel changes, or reduced appetite that feels too intense Hydration and nutrition: eating less doesnt mean neglecting protein, fluids, or meal structure Dose timing and consistency: keeping the schedule steady helps both monitoring and adherence Safety review: making sure no new symptoms suggest a reason to pause or reassess Practical habits that make the first months smoother The medication is one tool

10.1038/s41392-020-00420-3