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However, intra-VTA Ex-4 did not change extinction following the reacquisition of alcohol self-administration or motivation for alcohol (Dixon et al., Nicotine Ex-4, at doses not affecting baseline locomotor activity, reduced nicotine-induced locomotor behavior, accumbal dopamine release, and blocked nicotine-induced CPP in mice

Moreover, a peripherally administered GLP-1R antagonist increased alcohol consumption while GLP-1R activation in the VTA was sufficient to reduce alcohol consumption in rats, indicating that the effect may be mediated by GLP-1R in the VTA (Shirazi et al., 2013)

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If it continues, GERD can cause scarring and narrowing of the esophagus and increase a person's risk of esophageal cancer