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A 2022 review of semaglutide as a treatment for overweight and obesity recorded an average reduction in body weight of 14.44% in STEP clinical trial participants after 68 weeks of 2.4mg weekly injections

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UK guidance on managing GLP-1 medications around surgery is evolving as clinical experience with these agents increases

While this finding has not been confirmed in humans during extensive clinical trials and post-marketing surveillance, the FDA requires a boxed warning on GLP-1 receptor agonist labels regarding this potential risk