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NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes

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[11] In one crossover study, patients with bipolar disorder on lithium were given either 15 mg or 300 mg of MB daily, and those on the higher dose experienced significantly less depression, suggesting efficacy at that dose, though side effects and long-term safety at such high doses remain concerns