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Cardiovasc Res 43(3):521531 Rosales MA et al (2014) S-nitrosoglutathione inhibits inducible nitric oxide synthase upregulation by redox posttranslational modification in experimental diabetic retinopathy

384,385 Additionally, GWAS has identified several novel genetic loci associated with DPN, underscoring the complex genetic architecture underlying this condition

These changes likely contribute to easier sleep initiation, deeper delta-dominant sleep, and adaptogenic/stress-protective effects without strong sedation