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CYP2J2-produced epoxyeicosatrienoic acids contribute to the ferroptosis resistance of pancreatic ductal adenocarcinoma in a PPARgamma-dependent manner
Despite the identification of N-acetyl cysteine, a reactive oxygen species scavenger that is regarded as an effective clinical treatment, therapeutic effectiveness remains limited due to rapid disease progression and diagnosis at a late phase, which leads to the need to explore various therapeutic approaches
Molecular clocks have been discovered in immune cells including macrophages/monocytes, T cells, NK cells, dendritic cells, and B cells (Ella et al., 2016), along with a circadian regulation in recruitment and infiltration of immune cells including neutrophils, monocytes/macrophages, and T cells, which infiltrate the injury site after the integrity of the BBB is compromised (Scheiermann et al., 2013)
CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells
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