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Real-world experience often reveals effects not captured in controlled trials, particularly among patients with specific genetic variants, baseline inflammatory markers, or rapid weight-loss patterns that may interact with tirzepatide's metabolic effects
The first GLP-1RA approved for obesity was liraglutide in 2014, under the name Saxenda, while a higher-dose version of semaglutide was approved under the name Wegovy in 2021
Semaglutide is mainly used to treat type 2 diabetes and can also help with weight loss when combined with diet and exercise
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