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If the dog has known liver disease, treat any sudden lethargy, vomiting, or appetite collapse as a reason to call the clinic rather than waiting for vitamins to kick in. Eyes, Tissues, and the Cost of Deficiency Older veterinary literature describes riboflavin deficiency affecting the eyes in dogs, a reminder that B2 is not cosmeticit is functional tissue support tied to cellular energy handling (Spies, 1943)

Roy R, Haase T, Ma N, et al

Liver-derived acylcarnitine can serve as an energy substrate, particularly during prolonged exercise or fasting