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In summary, the perioperative period is a perfect storm for immune cell mitochondria: abrupt environmental changes (oxygen, temperature, blood flow), massive inflammatory and neuroendocrine signals, and high energy demands all converge on immune cell metabolic pathways

10.1016/j.yhbeh.2011.12.003 [DOI] [PMC free article] [PubMed] [Google Scholar] 17.Walum H, Waldman I, Young L

This perspective allows weight management discussions to stay grounded in the medical context rather than isolated numbers

Medications like GLP-1 agonists may help reduce physiological drive and cravingbut they dont address shame, broken identity, trauma, loneliness, or spiritual emptiness