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Weight loss typically continues, with clinical trials showing that semaglutide 2.4 mg (Wegovy) produces average weight loss of approximately 15% by week 68, while tirzepatide (Zepbound) has demonstrated weight loss of approximately 15-21% across different doses by week 72

Data shows unopened, boxed experience temperature fluctuations 50-70% slower than loose exposed to air currents during a typical 15-second fridge door opening, maintaining 1.5C (2.7F) variation inside the box compared to 3C (5.4F) outside it

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doi:10.1016/j.chest.2018.09.004 9 Bolisetty S, Zarjou A, Agarwal A