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In the body, hydroxocobalamin is converted to the active form of vitamin B12, methylcobalamin

and critically human PK data (unavailable because no completed clinical trials have been published)

These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Reconstituting and self-administering peptides carries inherent risks including infection, contamination, and dosing errors